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The interaction between endothelial cells and pericytes during angiogenesis is regulated, in part, by Ang-1/Tie-2, TGF-, and PDGF signaling (Kelly-Goss et al., 2014)

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A 2017 study by Hsieh and colleagues in Journal of Molecular Medicine reported that BPC-157, in chick chorioallantoic membrane, rat hind-limb ischemia, and HUVEC models, directionally increased vessel density, accelerated blood-flow recovery in ischemic muscle, and time-dependently activated the VEGFR2-Akt-eNOS signaling pathway via VEGFR2 internalization a mechanistic preclinical finding for which numeric effect sizes are not reported in the abstract